Clofarabine in the treatment of poor ris
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Janusz Krawczyk; Naeem Ansar; Ronan Swords; Tracy Murphy; Barry MacDonagh; Teres
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Article
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2009
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John Wiley and Sons
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English
β 92 KB
## Abstract Clofarabine is a second generation nucleoside analogue. It inhibits DNA repair and activates the mitochondrial apoptotic pathway leading to cell death. __In vitro__ clofarabine has demonstrated synergy with daunorubicin and AraβC and in phase II clinical trials has shown promising activ