✦ LIBER ✦

Tin(IV)-functionalised polymer supports; non-toxic and practical reagents for regioselective acetylation of sucrose

✍ Scribed by Wallace M. Macindoe; Andrew Williams; Riaz Khan

Book ID: 102994076
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 599 KB
Volume: 283
Category: Article
ISSN: 0008-6215
DOI: 10.1016/0008-6215(95)00392-4

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✦ Synopsis

Polymer-supported butyltin(IV) reagents have been surveyed for regioselectivity in acetylation of sucrose. Polymer-supported butyltin(IV) dichloride 8 catalysed the acetylation of sucrose to give a 59% yield of 6-O-acetyl sucrose 3, the precursor of sucralose. The yield is close to that of a previously reported process involving dibutyltin(IV) oxide (Bu2SnO). The spent polymeric resin could readily be regenerated and can be subsequently used in further synthetic reactions.