โ Scribed by Rowe, L.W. ;Scoville, Wilbur L.
No coin nor oath required. For personal study only.
This paper is a continuation of the work reported to this Section two years ago. In November 1931, a second series of tinctures was prepared from a defatted For Series A, 125 Gm. of the drug was extracted with 77a/, alcohol and 1150 cc.
This percolate was then drug assaying 200 per cent of standard.
of tincture was obtained, this being 92% of the full yield. divided into five portions of 230 cc. each and numbered successively.
No. 1 was diluted to 250 cc. with 77% alcohol.
No. 2 was adjusted to a P H of 2.93 by the addition of 1.5 cc. of hydrochloric acid, then made up to a volume of 250 cc. by the addition of 2.5 cc. of water and 16 cc. of alcohol.
No. 3, which had an initial p H of 5.56, was adjusted to a pH of 6.76 by the addition of sodium hydroxide solution, then made up to a volume of 250 cc. with 77% alcohol.
To No. 4 was added 2.5 cc. of glacial acetic acid, then 15 Gm. of anhydrous sodium acetate was dissolved in the liquid and the final volume was adjusted to 250 cc. by addition of alcohol.
No. 5 was treated with 50 Gm. of anhydrous sodium sulphate, the mixture being agitated frequently during one week, then filtered and the filter washed with 95% alcohol to obtain a yield of 250 cc. This assayed 78.6y0 of alcohol and showed a PH of 5.41. ~~ ~ ~~~ * Scientific Se'ction, A. PH. A,, Madison meeting, 1933.
This paper represents the first part of a dissertation to be submitted to the Graduate School by Mr. Stockhaus in partial fulfilment of the requirements for the degree of Doctor of Philosophy in the University of Michigan.
Mr. Stockhaus is the present Frederick Stearns and Company Fellow.
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