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TIMP-3 mRNA is not overexpressed in sorsby fundus dystrophy

โœ Scribed by Ngai Hang Victor Chong; Anders Kvanta; Stefan Seregard; Alan C Bird; Philip J Luthert; Bjorn Steen


Book ID
117019182
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
64 KB
Volume
136
Category
Article
ISSN
0002-9394

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Sorsby fundus dystrophy mutation Timp3S1
โœ Galina Soboleva; Birgit Geis; Heinrich Schrewe; Bernhard H.F. Weber ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 301 KB

## Abstract The tissue inhibitor of metalloproteinasesโ€3 (TIMP3) is a multifunctional protein tightly associated with the extracellular matrix (ECM). A specific type of mutation in TIMP3 which results in potentially unpaired cysteine residues at the Cโ€terminus of the protein has been shown to cause