Timed-release depot for anticancer agents

✍ Scribed by Seymour Yolles; Thomas D. Leafe; Francis J. Meyer

• Book ID: 102404703
• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: English
• Weight: 183 KB
• Volume: 64
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600640124

✦ Synopsis

The timed-release of anticancer agents from composites with poly(1actic acid) was studied in rats. In the case of cyclophosphamide-poly(1actic acid) composites, 67% of the administered dose was released within 34 days. With cis-dichlorodiammineplatinum (II), the amount of drug released was only 9.3% within the same period. This difference might be attributed to the different solubilities of these two drugs in the polymer. Electron spectroscopy chemical analysis, a new tool, was used to investigate the extent of diffusion of drugs in polymer films.

Keyphrases 0 Cyclophosphamide-timed-release formulation with poly(1actic acid), release characteristics, electron spectra cis-Dichlorodiammineplatinum (11)-timed-release formulation with poly(1actic acid), release characteristics, electron spectra Anticancer agents-poly(1actic acid) timed-release formulations of cyclophosphamide and cis -dichlorodiammineplatinum (11) 0 Timed-release formulations-cyclophosphamide and cisdichlorodiammineplatinum (11) with poly(1actic acid)