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Time-resolved laser-induced fluorescence spectroscopy for enhanced demarcation of human atherosclerotic plaques

✍ Scribed by S. Andersson-Engels; J. Johansson; U. Stenram; K. Svanberg; S. Svanberg

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
500 KB
Volume
4
Category
Article
ISSN
1011-1344

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✦ Synopsis

We report on the enhanced demarcation between human atherosclerotic plaques and normal vessel wall obtained using time-resolved detection of laser-induced fluorescence rather than the customary time-integrated monitoring technique. A frequency-doubled mode-locked and cavity-dumped continuous wave dye laser was used for picosecond pulse generation at 320 nm, and photon-counting techniques were employed for the time-resolved signal monitoring from human aorta samples in vitro. Implications for imaging fluorescence angioscopy and spectroscopic guidance in laser ablation of plaque are indicated.

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