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Time-dependent variations of drug-metabolising enzyme activities (DMEs) in primary cultures of rabbit hepatocytes

✍ Scribed by C Eeckhoutte; A Giuliano Albo; M Carletti; A Rossetto Giaccherino; P Galtier; C Nebbia; M Dacasto


Book ID
117587511
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
141 KB
Volume
16
Category
Article
ISSN
0887-2333

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## Abstract Primary cultures of human hepatocytes and hepatoma cell line HepG2 are frequently used to evaluate the hepatic disposition of drugs and other xenobiotics. To check the variability of the expression of drug‐metabolizing enzymes in these in vitro models, expression of genes coding for sev