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Time-dependent variations in the organ extraction ratios of acetaminophen in rat

✍ Scribed by Pierre M. Bélanger; Marcel Lalande; François Doré; Gaston Labrecque

Book ID
112473581
Publisher
Springer
Year
1987
Tongue
English
Weight
693 KB
Volume
15
Category
Article
ISSN
1573-8744

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The pharmacokinetics of acetaminophen was examined in rats after administration of a single dose of 200 mg kg-1 by the intra-arterial, intravenous, portal vein, and oral routes. Levels of acetaminophen and its two major metabolites, acetaminophen-glucuronide and acetaminophen-sulfate, were quantitat