Time dependent phenomena during the solvent induced coil to helix transition of poly α l glutamic acid in aqueous mixed solvents

✍ Scribed by M. Morcellet; C. Loucheux

• Publisher: Elsevier Science
• Year: 1978
• Tongue: English
• Weight: 448 KB
• Volume: 14
• Category: Article
• ISSN: 0014-3057
• DOI: 10.1016/0014-3057(78)90016-2

✦ Synopsis

Abslract--The variation of the conformation of poly (a L glutamic acid) (PLGA) in water-organic solvent mixtures has been studied as a function of time. These time dependent changes of the conformation have been observed in many water-organic solvent systems. The velocity of this phenomenon is very sensitive to the ionic strength of the solution. The origin of the time dependence of the conformation is discussed in relation with the preferential and absolute solvation of the polymer by the components of the solvent mixture.

R6sum6--Les changements de conformation de l'acide poly (~t L glutamique) (PLGA) dans des m61anges eau-solvant organique, ont 6t~ 6tudi6s en fonction du temps. Ces changements de conformation au cours du temps sont observ6s dans de nombreux syst6mes eau-solvant organique. De plus la vitesse de ce ph6nom6ne d6pend fortement de la force ionique de la solution. L'origine du changement de conformation en fonction du temps est discut6e en fonction de la sotvatation pr6f6rentielle et absolue du polym6re par les constituants du m61ange des solvants.