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Time-dependent kinetics III: Diurnal oscillations in steady-state plasma valproic acid levels in rhesus monkeys

✍ Scribed by R. H. Levy; J. S. Lockard; I. H. Patel; W. C. Congdon


Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
358 KB
Volume
66
Category
Article
ISSN
0022-3549

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Time-dependent kinetics II: Diurnal osci
✍ Indravadan H. Patel; RenΓ© H. Levy; Joan S. Lockard πŸ“‚ Article πŸ“… 1977 πŸ› John Wiley and Sons 🌐 English βš– 447 KB

Morning steady-state (9 am) plasma levels were significantly higher than the corresponding evening (5 pm) plasma levels during a 3-week zero-order infusion of ethosuximide to six monkeys. These differences could not be explained by experimental variables such as GLC assay and infusion pump. Circadia