Time Course of the Cellular Reaction Toward Microencapsulated Xenogeneic Islets in the Rat
โ Scribed by U. Siebers; A. Horcher; H. Brandhorst; D. Brandhorst; K. Federlin; R.G. Bretzel; T. Zekorn
- Book ID
- 117235720
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 116 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0041-1345
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๐ SIMILAR VOLUMES
Microencapsulation has been proposed to protect islets of Langerhans against immune rejection in xenogenic transplantation. However, to achieve glucose homeostasis in human diabetic patients, insulin release by microencapsulated islets must increase in response to a glucose load. We microencapsulate
Appropriate insulin therapy may preserve or improve islet B-cell function whereas the effects of overinsulinisation are unclear. Pancreatic islet B-cell function was therefore studied after overinsulinisation of normal rats for 4 weeks (fed blood glucose 2.2-4.5 mmol/l, controls 4.1-7.0 mmol/l). Ins