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Time-course of physical abstinence and tolerance recovery after spinal continuous infusion of μ agonists in the rat

✍ Scribed by Sosnowski, M.; Yaksh, T.L.

Book ID
122996288
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
144 KB
Volume
41
Category
Article
ISSN
0304-3959

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Rats were treated by intragastric intubation of a 20 % ethanol solution in doses of 9-15 g/kg in 3-5 fractions for 1-7 days. Both tolerance and physical dependence were demonstrated after this treatment with the maximum tolerable doses to only a few days. Tolerance was assessed by signs of severity