Time Course and Site(s) of Cytochrome c Tyrosine Nitration by Peroxynitrite †
✍ Scribed by Batthyány, Carlos; Souza, José M.; Durán, Rosario; Cassina, Adriana; Cerveñansky, Carlos; Radi, Rafael
- Book ID
- 120156303
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 316 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0006-2960
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📜 SIMILAR VOLUMES
Peroxynitrite, which is formed in biological systems by the reaction of nitric oxide with superoxide anion, is a highly reactive molecule that can lead to cell injury or cell death. Reactions of peroxynitrite under physiological conditions include nitration of tyrosinecontaining proteins or peptides
Tyrosines can be selectively nitrated in a protein and the resultant chromophore can be used as an in situ probe of the tyrosine environment. Resonance Raman scattering could have specific advantages as a detection method because of the inherent selectivity of the technique and because shifts in the