Time course and mechanism of alterations in proton relaxation during liver regeneration in the rat

✍ Scribed by H. Dirk Sostman; John C. Gore; M. Wayne Flye; G. Allan Johnson; Robert J. Herfkens

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 591 KB
• Volume: 5
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.1840050403

✦ Synopsis

We studied the proton Ti and Tz, water and lipid content of regenerating rat liver from 1 to 7 days after 70% hepatectomy. Liver from normal and sham-operated animals and splenic tissue from all animals were studied as controls. I n uiuo proton spectroscopy and imaging of liver was performed in a separate group of control and posthepatectomy rats. The Tz of regenerating liver, but not of sham or normal control liver, was prolonged. Changes in Ti, relative to normal tiseue, were found in liver and spleen of both operated groups. Lipid content, 889es88d both by extraction of tissue samples and by in uiuo spectroscopy, was increased in regenerating tissue but not in controls. Water content was similarly increased in regenerating liver tissue. Changes in water and lipid content appeared to contribute to the alterations in proton relaxation which we observed.