Time and temperature dependence of MR parameters during thermal coagulation of ex vivo rabbit muscle
✍ Scribed by Simon J. Graham; Michael J. Bronskill; R. Mark Henkelman
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 672 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
Detailed measurements of the T~1~‐weighted, T~2~‐weighted, and MT‐weighted signal were performed for ex vivo muscle samples heated to various temperatures for different times. Consistent, monotonic increases in signal intensity were observed with progressive thermal coagulation, corresponding to an increase in T~2~ relaxation time and an increase in MT‐weighted signal for temperatures above 60°C. The relationship for T~1~ relaxation was more complex, showing a decrease in T~1~ relaxation from 40 to 60°C and an increase above 60°C. These techniques provide a more direct measure of tissue thermal coagulation than that provided by MR thermometry and suggest MR imaging strategies for the optimization and monitoring of thermal coagulation therapy protocols that create thermal damage in target tissues.