The effects of a 5-HT1receptor ligand is
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G. M. Goodwin; Rosemarie J. Souza; A. R. Green
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Article
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1986
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Springer
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English
⚖ 557 KB
The effects of 2-(4-(4-(2-pyrimidinyl)-l-piperazinyl)-butyl)-1,2-benzoisothiazol-3(2H)one-1,1-dioxide hydrochloride (isapirone, TVX Q 7821), a putative 5-HT1 receptor antagonist, has been studied on various models of 5-HT receptor sub-type function. In mice TVX Q 7821 produced a dose-dependent inhib