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Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1

✍ Scribed by Fukuhara, Shigetomo; Sako, Keisuke; Noda, Kazuomi; Nagao, Kaori; Miura, Koichi; Mochizuki, Naoki

Book ID
120282617
Publisher
Korean Society of Medical Biochemistry and Molecular Biology
Year
2009
Tongue
English
Weight
508 KB
Volume
41
Category
Article
ISSN
1226-3613

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## Abstract Angiopoietins are ligands of the endothelial cell tyrosine kinase receptor Tie2. Angiopoietin‐1 (Ang‐1) is widely expressed in human normal adult tissues and promotes blood vessel maturation and stabilization by inducing Tie2 receptor phosphorylation. In contrast, the antagonistic ligan