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Tiamdipines: A new class of Ca++-antagonists

โœ Scribed by C.A. Gandolfi; M. Frigerio; C. Riva; A. Zaliani; A. Passoni; M. Germini; B. Lumachi; O. Tofanetti


Book ID
114075597
Publisher
Elsevier Science
Year
1988
Weight
78 KB
Volume
20
Category
Article
ISSN
0031-6989

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Pyrrolylquinoxalinediones were synthesized and their affinities for the AMPA receptor were determined. Most compounds showed moderate to good affinities. The acetic acid derivative 8b exhibited a K~ value of 70 nM and was equipotent to NBQX 1. Structure activity relationships are discussed. Selected