Tiagabine for essential tremor: An open-label trial
✍ Scribed by Alexandre Gironell; Mercè Martínez-Corral; Xavier Pagonabarraga; Jaime Kulisevsky
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 41 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
✦ Synopsis
We agree with Zesiewicz et al.'s findings and emphasize that simply increasing GABAergic stimulation does not necessarily result in tremor improvement in ET. It is clear that more needs to be learnt on the pharmacologic basis of ET.
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We conducted a double-blind trial of isoniazid in 11 patients with essential tremor and four patients with other types of postural action tremor. The tremor had not been helped by beta-blockers or primidone. Isoniazid was given in doses up to 1,200 mg daily, together with 100 mg pyridoxine, for four
## Abstract Early side effects are common when primidone is used to treat essential tremor, with as many as one‐third of patients failing to tolerate the tablets. Lower doses can be prescribed initially using a suspension formulation. We suspected suspension initiation would result in fewer early s