Terahertz (THz) spectroscopy and chemometric analysis of resultant absorption spectra in the 30-500 cm(-1) range has been applied to perform quantitative determination of both active ingredient and excipient concentrations of tablets. Tests were performed on a series of tablets composed of various c
โฆ LIBER โฆ
THz spectroscopy: An emerging technology for pharmaceutical development and pharmaceutical Process Analytical Technology (PAT) applications
โ Scribed by Huiquan Wu; Mansoor Khan
- Book ID
- 113806363
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 664 KB
- Volume
- 1020
- Category
- Article
- ISSN
- 0022-2860
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In this work, an integrated PAT approach was developed for monitoring a pharmaceutical (naproxen) and a polymer (eudragit) coprecipitation process: real-time in-line near-infrared (NIR) absorbance monitoring, real-time on-line turbidity monitoring, and in situ crystal size monitoring. The data and i