Thyroid hormone induces cerebellar neuronal migration and Bergmann glia differentiation through epidermal growth factor/mitogen-activated protein kinase pathway

Proliferation of cerebellar neurons indu

Proliferation of cerebellar neurons induced by astrocytes treated with thyroid hormone is mediated by a cooperation between cell contact and soluble factors and involves the epidermal growth factor-protein kinase a pathway

✍ Rodrigo Martinez; Flávia Carvalho Alcantara Gomes 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 298 KB

## Abstract Cerebellar development is fully dependent on thyroid hormone (T3) levels. We have previously demonstrated a glia‐mediated effect of T3 on cerebellar neurons. We have reported that cerebellar astrocytes treated with thyroid hormone secrete epidermal growth factor (EGF), which directly in