✦ LIBER ✦
Thyroid hormone analogues potentiate the antiviral action of interferon-γ by two mechanisms
✍ Scribed by H.-Y. Lin; H.R. Thacore; F.B. Davis; P.J. Davis
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 979 KB
- Volume
- 167
- Category
- Article
- ISSN
- 0021-9541
No coin nor oath required. For personal study only.
✦ Synopsis
L-thyroxine (L-T,) potentiates the antiviral activity of human interferon-y (IFN-.I) in HeLa cells. We have added thyroid hormone and analogues to cells either 1 )
for 24 h pretreatment prior to 24 h of IFN-y (1 .O IU/ml), 2) for 24 h cotreatment with IFN-y, 3) for 4 h, after 20 h cell incubation with IFN-y, alone, or 4) for 24 h pretreatment and 24 h cotreatment with IFN-y. The antiviral effect of IFN-y was then assayed. L-T4 potentiated the antiviral action of IFN-y by a reduction in virus yield of more than two logs, the equivalent of a more than 1 00-fold potentiation