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Thyroid function in children with cystic fibrosis

✍ Scribed by F. Luca; F. Trimarchi; C. Sferlazzas; S. Benvenga; G. Costante; C. Mami; G. Pasquale; G. Magazzu

Publisher: Springer
Year: 1982
Tongue: English
Weight: 316 KB
Volume: 138
Category: Article
ISSN: 0340-6997
DOI: 10.1007/bf00442510

No coin nor oath required. For personal study only.

✦ Synopsis

Serum concentrations of T4, T3, reverse T3 (rT3), TSH, Thyroxine binding globulin (TBG) and Thyroxine binding prealbumin (TBPA) were measured and a TRH-stimulation test was performed in 10 iodide untreated children affected by cystic fibrosis (CF) and in 84 controls.

As compared to the controls, CF patients had lower T4 and rT3, similar T3 and TBG and increased T3 : T4 ratios. They also had lower TBPA, but this could not account for the low T4. Finally they had higher basal and TRH-stimulated TSH.

Our results indicate subclinical hypothyroidism in CF. The mechanisms responsible for this situation are not elucidated by our data.

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