Thyroglobulin may be undetectable in the serum of patients with metastatic disease secondary to differentiated thyroid carcinoma. Follow-up of differentiated thyroid carcinoma

✍ Scribed by Simon Grant; Brian Luttrell; Thomas Reeve; Josephine Wiseman; Errol Wilmshurst; John Stiel; Diane Donohoe; Robert Cooper; Margaret Bridgman

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 485 KB
• Volume: 54
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19841015)54:8<1625::aid-cncr2820540825>3.0.co;2-0

✦ Synopsis

To assess the value of serum thyroglobulin (Tg) levels in the follow-up of differentiated thyroid carcinoma after ablative therapy simultaneous Tg estimations and radioiodine (I3'I) scans were performed on patients during an 18-month follow-up period. In this study, 287 scans were performed on 200 patients who were not receiving Thyroxine (T4) replacement at the time, Le.. off T4. Wherever possible, Tg was also estimated while the patient was receiving T4. All sera were screened for Tg autoantibodies which were detected on 67 occasions in 44 patients (22%). Of the 220 sera without Tg autoantibodies (156 patients), 17 were accompanied by scan evidence of functioning thyroid tissue, although Tg was undetectable