Thymosin β-10 expression in melanoma cell lines and melanocytic lesions: A new progression marker for human cutaneous melanoma
✍ Scribed by Marian A. J. Weterman; Goos N. P. Van Muijen; Dirk J. Ruiter; Henri P. J. Bloemers
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- French
- Weight
- 864 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
When screening a subtraction library for sequences that were specifically expressed in highly metastatic human melanoma cell lines, a cDNA clone was isolated encoding thymosin p-10. We found that expression of thymosin p-I0 mRNA was associated with metastatic behavior of various human melanoma cell lines in nude mice. Furthermore, Northern blot analysis showed that also in freshly harvested human melanocytic lesions thymosin p-10 was differentially expressed. Although expression of thymosin @-I0 was also examined in other non-melanoma model systems and materials, no clear relation could be established with metastatic potential or malignancy. Therefore, we conclude that thymosin p-I0 can be considered as a new progression marker for human cutaneous melanoma.