✦ LIBER ✦

Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells

✍ Scribed by Harald von Boehmer; Katrin Schubiger

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 522 KB
Volume: 14
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830141116

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✦ Synopsis

Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells

BALBlc nulnu mice were grafted with embryonic 14-day-old C57BL16 thymi which were transplanted either nontreated or after elimination of hemopoietic cells with 2deoxyguanosine. In both types of grafts host cells developed normally into functional thymocytes. Thymocytes from 2-deoxyguanosine-treated but not from untreated grafts contained as many cytolytic T lymphocyte precursors specific for class I MHC antigens on thymus epithelium as normal BALB/c thymocytes. As cytolytic T lymphocyte precursors were neither suppressed nor activated in these grafts it is concluded that thymocytes ignore class I M H C antigens expressed on thymus epithelium.

We thank Drs. W .

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