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Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels

✍ Scribed by Binh N. Trinh; Choon-Nam Ong; Gerhard A. Coetzee; Mimi C. Yu; Peter W. Laird


Publisher
Springer
Year
2002
Tongue
English
Weight
65 KB
Volume
111
Category
Article
ISSN
0340-6717

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Folic acid administration to women in the periconceptional period reduces the occurrence of neural tube defects (NTDs) in their offspring. A polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), 677C¨T, is the first genetic risk factor for NTDs in man identified at the molec