Major subdomain rearrangement in HIV-1 r
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M. Madrid; A. Jacobo-Molina; J. Ding; E. Arnold
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Article
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1999
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John Wiley and Sons
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English
β 132 KB
We have performed eight 1-ns in vacuo molecular dynamics simulations of HIV-1 reverse transcriptase (RT). Starting with the p66 thumb subdomain in an upright configuration, the p66 thumb moved down over the palm during six of the eight trajectories, in excellent agreement with the crystallographic s