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Thumbs Down: Subdomain Rearrangements in the Drug Bound HIV-1 Reverse Transcriptase

✍ Scribed by Wright, David W.; Sadiq, S. Kashif; Coveney, Peter V.


Book ID
119209639
Publisher
Biophysical Society
Year
2012
Tongue
English
Weight
35 KB
Volume
102
Category
Article
ISSN
0006-3495

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Major subdomain rearrangement in HIV-1 r
✍ M. Madrid; A. Jacobo-Molina; J. Ding; E. Arnold πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 132 KB

We have performed eight 1-ns in vacuo molecular dynamics simulations of HIV-1 reverse transcriptase (RT). Starting with the p66 thumb subdomain in an upright configuration, the p66 thumb moved down over the palm during six of the eight trajectories, in excellent agreement with the crystallographic s