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Through-Bond Correlation of Sugar and Base Protons in Unlabeled Nucleic Acids

✍ Scribed by Anh Tuân Phan

Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
73 KB
Volume
153
Category
Article
ISSN
1090-7807

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✦ Synopsis

This work presents two methods for through-bond correlation between sugar and base protons in view of model-independent assignment in unlabeled or slightly enriched nucleic acids. Each method uses a combination of multiple-bond and one-bond heteronuclear J-couplings to the aromatic carbon C6 for pyrimidines ( 3 J H1 ,C6 and 1 J H6,C6 ) or C8 for purines ( 3 J H1 ,C8 and 1 J H8,C8 ). The techniques are demonstrated in the duplex [d(CGCGAATTCGCG)] 2 and the dimeric G-quadruplex [d(GGGTTCAGG)] 2 at natural abundance.

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