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Thrombospondin-1 promotes fibroblast-mediated collagen gel contraction caused by activation of latent transforming growth factor β-1

✍ Scribed by Sakai, Kensuke; Sumi, Yukio; Muramatsu, Hisako; Hata, Ken-ichiro; Muramatsu, Takashi; Ueda, Minoru


Book ID
119561001
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
485 KB
Volume
31
Category
Article
ISSN
0923-1811

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Transforming growth factor-beta1 (TGF-beta) is secreted in a latent form consisting of mature TGF-beta noncovalently associated with its amino-terminal propeptide, which is called latency associated peptide (LAP). Biological activity depends upon the release of TGF-beta from the latent complex follo