Thrombophilia and fetal loss

✍ Scribed by B. Brenner; Z. Blumenfeld

• Book ID: 104323297
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 984 KB
• Volume: 11
• Category: Article
• ISSN: 0268-960X
• DOI: 10.1016/s0268-960x(97)90013-8

✦ Synopsis

Recurrent fetal loss and other placental vascular pathologies of pregnancy have long been associated with antiphospholipid syndrome -an acquired autoimmune thrombophilic state. The number of known heritable thrombophilic disorders has grown rapidly in recent years with the identification of activated protein C resistance, factor V Leiden mutation and hyperhomocysteinemia as major causes of thrombosis. Data accumulated over the past two years suggest that heritable thrombophilia is associated with increased risk of fetal loss and pre-eclampsia. The present review discusses potential pathogenetic mechanisms for this association and evaluates reported therapeutic regimes for the prevention of fetal loss in women with thrombophilia.