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Thrombomodulin Tightens the Thrombin Active Site Loops To Promote Protein C Activation †

✍ Scribed by Koeppe, Julia R.; Seitova, Almagoul; Mather, Timothy; Komives, Elizabeth A.

Book ID
125986593
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
270 KB
Volume
44
Category
Article
ISSN
0006-2960

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Protein C (PC) is activated to an essential anticoagulant enzyme (activated PC or APC) by thrombin (T) bound to thrombomodulin (TM), a membrane receptor present on the surface of endothelial cells. The understanding of this complex biological system is in part limited due to the lack of integration