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Thrombin-induced p38 mitogen-activated protein kinase activation is mediated by epidermal growth factor receptor transactivation pathway

โœ Scribed by Yasunari Kanda; Katsushige Mizuno; Yasutomi Kuroki; Yasuhiro Watanabe


Book ID
110005604
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
417 KB
Volume
132
Category
Article
ISSN
0007-1188

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We have previously shown that p38 mitogen-activated protein kinase (MAPK) inhibitors, which block the production and action of inflammatory cytokines such as tumor necrosis factor (TNF) and interleukin-1 (IL-1), are effective in models of bone and cartilage degradation. To further investigate the ro