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THROMBIN ENHANCEMENT OF INTERLEUKIN-1 EXPRESSION IN MONONUCLEAR CELLS: INVOLVEMENT OF PROTEINASE-ACTIVATED RECEPTOR-1

✍ Scribed by Antonella Naldini; Annalisa Pucci; Darrell H Carney; Giuseppe Fanetti; Fabio Carraro

Book ID
115596913
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
336 KB
Volume
20
Category
Article
ISSN
1043-4666

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## Abstract Thrombin increases the cytosolic Ca^2+^ concentrations and induces NO production by activating proteinase‐activated receptor 1 (PAR~1~) in vascular endothelial cells. The store‐operated Ca^2+^ influx is a major Ca^2+^ influx pathway in non‐excitable cells including endothelial cells and