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Thrombin-activated and factor Xa-activated human factor VIII: Differences in cofactor activity and decay rate

โœ Scribed by Pierre F. Neuenschwander; Jolyon Jesty

Book ID
115709275
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
1008 KB
Volume
296
Category
Article
ISSN
0003-9861

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The factor VIII procofactor circulates as a metal ion-dependent heterodimer of a heavy chain and light chain. Activation of factor VIII results from limited proteolysis catalyzed by thrombin or factor Xa, which binds the factor VIII substrate over extended interactive surfaces. The proteases efficie