Three solutions of the protein solubility problem

✍ Scribed by W. Terry Jenkins

• Book ID: 105356511
• Publisher: Cold Spring Harbor Laboratory Press
• Year: 2008
• Tongue: English
• Weight: 521 KB
• Volume: 7
• Category: Article
• ISSN: 0961-8368
• DOI: 10.1002/pro.5560070218

✦ Synopsis

Abstract

Three simple equations are presented, which describe the variation of protein solubility (S) with changes in salt concentration, in terms of either the salt molality (M), the salt activity (a~x~), or the water activity (a~w~). Each equation yields, essentially independent, estimates of the numbers of salt ions (Δ__v~x~) and water molecules (Δ__v~w~) involved in the dissolution of a mol of the protein. The equations can be used to elucidate the physical significance of the parameters in other empirical equations for protein solubility.