Three novel and one new lignan, chamaecypanones A, B, obtulignolide and isootobanone from the heartwood of Chamaecyparis obtusa var. formosana

✍ Scribed by Yueh-Hsiung Kuo; Chia-Hsien Chen; Yi-Ming Chiang

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 220 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01272-2

✦ Synopsis

Three novel lignans, chamaecypanone A 1, chamaecypanone B 2, obtulignolide 4, and one new lignan, isootobanone 3, were isolated from the heartwood of Chamaecyparis obtusa var. formosana, and were elucidated on the basis of 2D NMR techniques. Compounds 1 and 2, derived from a phenyltetrahydronaphthalene-type lignan by cleavage and cyclization, are anthrone derivatives. Compound 3 is a phenyltetrahydronaphthalene-type lignan, and 4 is a 3,4-secophenyltetrahydronaphthalenetype lignan. The absolute configurations of 3 and otobanone 5 were elucidated by a modified Mosher's method.