Three New Triterpenes from Xylarialean sp. A45, an Endophytic Fungus from Annona squamosa L.

✍ Scribed by Ting Lin; Xiao Lin; Chun-Hua Lu; Yue-Mao Shen

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: German
• Weight: 150 KB
• Volume: 94
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.201000220

✦ Synopsis

From the fermentation extract of Xylarialean sp. A45, an endophytic fungus of Annona squamosa L., three new triterpenes, namely xylariacins A -C (1 -3, resp.) were obtained. Their structures were determined by spectroscopic analyses, including 1D-and 2D-NMR experiments and HR-ESI-Q-TOF mass spectrometry. The in vitro cytotoxic activities of compounds 1 -3 were tested against human tumor cell line HepG2, and these compounds showed modest cytotoxic activity.