Three new taxane diterpenoids from the seeds of Taxus yunnanensis Cheng et L. K. Fu and T. cuspidata Sieb et Zucc

✍ Scribed by Qing-wen Shi; Takayuki Oritani; Takeyoshi Sugiyama; Tohru Horiguchi; Ryo Murakami; Ding Zhao; Takashi Oritani

• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 570 KB
• Volume: 55
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(99)00466-4

✦ Synopsis

Chemical examination of the seeds of the Chinese yew, Taxus yunnanensis Cheng et L. K. Fu and Japanese yew, T. cuspidata Sieb et Zucc resulted in the isolation of three new and rare rearranged abeotaxane type of diterpenoids in addition to several known compounds. The structures of the new taxoids have been established as 90t, 13a-diacetoxy-1 l(15--->l)abeotaxa-4(20), 1 ldiene-5ct, 10~, 15-triol (1), 9a, 13ct-diacetoxy-10~-benzoyloxy-5~-(3'-dimethylamino-3'-phenyl)-propionyloxy-11 ( 15---~ l)abeotaxa-4(20), 11 -diene-15-ol (2), and 2~,71~, 13a-triacetoxy-1013-hydroxy-5a-(3'-dimethylamino-3'-phenyl)-propionyloxy-2(3--->20)-abeo-taxa-9-one (3) by a study of their spectral data.