Three New Neolignans and One New Phenylpropanoid from the Leaves and Stems of Toona ciliata var. pubescens

✍ Scribed by Yu-Bo Liu; Jiang-Jiang Qin; Xiang-Rong Cheng; Jia-Xian Zhu; Fei Zhang; Hui-Zi Jin; Wei-Dong Zhang

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: German
• Weight: 169 KB
• Volume: 94
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.201100084

✦ Synopsis

Abstract

Three new neolignans, (7__S__,8__S__,7′E)‐4,9‐dihydroxy‐3,7,3′,9′‐tetramethoxy‐8,4′‐oxyneolign‐7′‐ene (1), (7__R__,8__S__,7′E)‐4, 9‐dihydroxy‐3,7,3′,9′‐tetramethoxy‐8,4′‐oxyneolign‐7′‐ene (2), (7__S__,8__S__,7′E)‐5, 9‐dihydroxy‐3,7,3′,5′,9′‐pentamethoxy‐8,4′‐oxyneolign‐7′‐ene (3), and one new phenylpropanoid, threo‐5‐hydroxy‐3,7‐dimethoxyphenylpropane‐8,9‐diol (4), were isolated from the leaves and stems of Toona ciliata var. pubescens. Their structures were determined on the basis of spectroscopic analysis, especially 2D‐NMR, HR‐ESI‐MS, and CD data. The antiproliferative activities of these compounds against four tumor cell lines (A549, Colo 205, QGY‐7703, and LOVO) were also evaluated by MTT (=(3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2__H__‐tetrazolium bromide) method.