Three New Medicagenic Acid Saponins from Polygala micranthaGuill. & Perr.

✍ Scribed by Turibio Kuiate Tabopda; Anne-Claire Mitaine-Offer; Tomofumi Miyamoto; Chiaki Tanaka; Bonaventure Tchaleu Ngadjui; Jean-François Mirjolet; Olivier Duchamp; Marie-Aleth Lacaille-Dubois

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: German
• Weight: 181 KB
• Volume: 94
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.201000331

✦ Synopsis

Abstract

Three new medicagenic acid saponins, micranthosides A–C (1–3), were isolated from the roots of Polygala micrantha Guill. & Perr., along with six known presenegenin saponins. Their structures were elucidated on the basis of extensive 1D‐ and 2D‐NMR experiments (^1^H, ^13^C, DEPT, COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectrometry as 3‐O‐β‐D‐glucopyranosylmedicagenic acid 28‐[O‐β‐D‐galactopyranosyl‐(1→4)‐O‐β‐D‐xylopyranosyl‐(1→4)‐O‐α‐L‐rhamnopyranosyl‐(1→2)‐β‐D‐fucopyranosyl] ester (1), 3‐O‐β‐D‐glucopyranosylmedicagenic acid 28‐[O‐6‐O‐acetyl‐β‐D‐galactopyranosyl‐(1→4)‐O‐β‐D‐xylopyranosyl‐(1→4)‐O‐α‐L‐rhamnopyranosyl‐(1→2)‐β‐D‐fucopyranosyl] ester (2), and 3‐O‐{O‐β‐D‐glucopyranosyl‐(1→3)‐O‐[β‐D‐glucopyranosyl‐(1→6)]‐β‐D‐glucopyranosyl}medicagenic acid 28‐{O‐β‐D‐apiofuranosyl‐(1→3)‐O‐β‐D‐xylopyranosyl‐(1→4)‐O‐[β‐D‐apiofuranosyl‐(1→3)]‐O‐α‐L‐rhamnopyranosyl‐(1→2)‐β‐D‐fucopyranosyl} ester (3). Compounds 1–3 were evaluated against HCT 116 and HT‐29 human colon cancer cells, but they did not show any cytotoxicity.