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Three New Indole-Containing Diketopiperazine Alkaloids from a Deep-Ocean Sediment Derived Fungus Penicillium griseofulvum

✍ Scribed by Li-Na Zhou; Tian-Jiao Zhu; Sheng-Xin Cai; Qian-Qun Gu; De-Hai Li

Publisher: John Wiley and Sons
Year: 2010
Tongue: German
Weight: 162 KB
Volume: 93
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200900443

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✦ Synopsis

Abstract

Three new indole‐containing diketopiperazine alkaloids, named variecolorins M–O (1–3), together with the eight known analogues 4–11, were isolated from a deep‐ocean sediment‐derived fungus, Penicillium griseofulvum. Their structures were determined by analysis of the spectroscopic data. The 2,2‐diphenyl‐1‐picrylhydrazinyl (DPPH) radical‐scavenging activities and the cell‐proliferation inhibitory activities of the three new compounds 1–3 were investigated.

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