Three New Eudesmanolactones (=Eudesmanolides) from Camchaya loloana

✍ Scribed by Chang-Song Li; Hong-Wei Yu; Xiao-Zhen Chen; Xiao-Qing Wu; Guo-You Li; Guo-Lin Zhang

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: German
• Weight: 169 KB
• Volume: 94
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.201000138

✦ Synopsis

Abstract

Three new eudesmanolactones (=eudesmanolides), loloanolide A (1), loloanolide B (2), and 1‐O‐acetylloloanolide B (3), together with five known compounds, were isolated from the CHCl~3~ extract of the aerial parts of Camchaya loloana. Their structures were elucidated on the basis of spectroscopic analysis. This type of eudesmanolactones bearing a 2‐(hydroxymethyl)acryloyloxy group at C(8) was discovered for the first time. Compounds 1–3 exhibited cytotoxicity against the HepG2 cell line, with GI~50~ values of 22.9, 18.1, and 12.8 nmol/ml, respectively.