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Three New ent-Labdane Diterpenoids from the Wood of Excoecaria agallochaLinn.

✍ Scribed by Ponnapalli Mangala Gowri; Sri Vedavyasa Srirangaraja Radhakrishnan Bhattar; Poreddy Guruva Reddy; Yerraballi Rakesh; Shaik Jeelani Basha; Akella Venkata Subrahmanya Sarma; Janaswamy Madhusudana Rao

Publisher
John Wiley and Sons
Year
2009
Tongue
German
Weight
200 KB
Volume
92
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

An extensive study of metabolites present in Excoecaria agallocha Linn. led to the isolation of three new ent‐labdane‐type diterpenoids, named agallochaexcoerins A–C (1–3), besides three known compounds. The skeleton present in compound 1 is rather unusual, containing of a seven‐membered lactone. The structures were elucidated on the basis of spectroscopic studies and comparison with known related compounds. The isolated compounds 1–6 were not active against Raw 264.7 (macrophage‐like), K 562 (leukemia), and COLO 205 (colon) human carcinoma cell lines.

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Nine New ent-Labdane Diterpenoids from the Aerial Parts of Andrographis paniculata
✍ Li-Xia Chen; Feng Qiu; Hong Wei; Ge-Xia Qu; Xin-Sheng Yao 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 German ⚖ 106 KB 👁 1 views

Nine new ent-labdane-type diterpenoids (1 -9), mostly in the form of the corresponding 16,15-lactones, were isolated from the 85%-EtOH extract of the aerial parts of Andrographis paniculata NEES., together with nine known compounds (10 -18). Their structures were deduced by in-depth NMR spectroscopy