Three New ent-Kaurane Diterpenoids from Siegesbeckia pubescens

✍ Scribed by Jia Liu; Lin Feng; Hai-Dao Li; Qing-Li Dong; Rong Chen

• Book ID: 102259431
• Publisher: John Wiley and Sons
• Year: 2012
• Tongue: German
• Weight: 185 KB
• Volume: 95
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.201100272

✦ Synopsis

Abstract

Three new ent‐kaurane glucopyranosides, 2‐O‐[β‐D‐apiofuranosyl‐(1→3)‐2‐O‐isovaleryl‐β‐D‐glucopyranosyl]‐4‐epi‐atractyligenin (1), 2‐O‐[β‐D‐apiofuranosyl‐(1→3)‐2‐O‐isovaleryl‐β‐D‐glucopyranosyl]atractyligenin (2), and 2‐O‐[β‐D‐apiofuranosyl‐(1→3)‐2‐O‐(3‐methylpentanoyl)‐β‐D‐glucopyranosyl]‐4‐epi‐atractyligenin (3), along with 2‐O‐(2‐O‐isovaleryl‐β‐D‐glucopyranosyl)‐4‐epi‐atractyligenin (4), were isolated for the first time from the aerial parts of Siegesbeckia pubescens. The structures were established by extensive spectroscopic analyses including 1D‐ and 2D‐NMR (HSQC, HMBC, and ROESY), and HR‐ESI‐MS, and by comparison with published data.