Three New Cytotoxic ent-Kaurane Diterpenoids from Isodon weisiensis C. Y. Wu

✍ Scribed by Lan Ding; Zhang-Jing Zhang; Guo-An Liu; Dong-Juan Yang; Guo-Cong Guo; Han Wang; Kun Sun

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: German
• Weight: 149 KB
• Volume: 88
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200590185

✦ Synopsis

Abstract

Three new cytotoxic ent‐kaurane diterpenoids, (1__α,7__α,14__β__)‐1,7,14‐trihydroxy‐ent‐kaur‐16‐en‐15,18‐dione (1), (1__α__,7__α__,14__β__)‐1,7,14,18,20‐pentahydroxy‐ent‐kaur‐16‐en‐15‐one (2), and (3__β__,7__α__,14__β__)‐3,7,14‐tris(acetyloxy)‐ent‐kaur‐16‐en‐15‐one (3), were isolated from Isodon weisiensis C. Y. Wu. Their structures were elucidated by spectroscopic methods, including 2D‐NMR techniques, and the crystal structure of 1 was determined by single‐crystal X‐ray‐diffraction analysis. The chosen crystal of 1 was orthorhombic, space group __P__2~1~2~1~2~1~, and there were two molecules with little difference in bond length and bond angle in the least‐asymmetry unit. Compounds 1–3 showed significant cytotoxic activities against human‐cancer cell lines Bel‐7402 and HO‐8910.