Three New Clerodane Diterpenoids from the Bulbils of Dioscorea bulbifera L. var. sativa

✍ Scribed by Rémy Bertrand Teponno; Azefack Léon Tapondjou; Hyun Ju-Jung; Jung-Hwan Nam; Pierre Tane; Hee-Juhn Park

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: German
• Weight: 89 KB
• Volume: 90
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200790168

✦ Synopsis

Abstract

From the bulbils of Dioscorea bulbifera L. var. sativa, three new clerodane diterpenoids, bafoudiosbulbin C (=methyl (2__β__,8__α__,12__S__)‐17‐oxo‐2,19 : 8,19 : 12,17 : 15,16‐tetraepoxycleroda‐3,13(16), 14‐triene‐18‐carboxylate; 1), bafoudiosbulbin D (=methyl (2__β__,6__β__,12__R__)‐17,19‐dioxo‐2,19 : 6,17 :  8,12 : 15,16‐tetraepoxycleroda‐13(16),14‐diene‐18‐carboxylate; 2), and bafoudiosbulbin E (=methyl (2__β__,3__α__,4__α__,6__β__,12__R__)‐17,19‐dioxo‐2,19 : 3,4 : 6,17 : 8,12 : 15,16‐pentaepoxycleroda‐13(16),14‐diene‐18‐carboxylate; 3) were isolated, together with the known compounds bafoudiosbulbins A and B, 3‐O‐β‐D‐glucopyranosyl‐β‐sitosterol, and 6′‐stearoyl‐3‐O‐β‐D‐glucopyranosyl‐β‐sitosterol. Their structures were established by high‐field NMR techniques (^1^H,^1^H‐COSY, ^13^C‐DEPT, HSQC, HMBC, and NOESY), MS analyses, as well as by comparison of their spectral data with those of related compounds.