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Three New 3,6-Dioxygenated Diketopiperazines from the Basidiomycete Lepista sordida

✍ Scribed by Xiang-Lian Chen; Min Wu; Hui-Hui Ti; Xiao-Yi Wei; Tai-Hui Li

Book ID: 102257580
Publisher: John Wiley and Sons
Year: 2011
Tongue: German
Weight: 165 KB
Volume: 94
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.201000455

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✦ Synopsis

Abstract

Three new 3,6‐dioxygenated diketopiperazines, lepistamides A–C (1–3), along with a known compound, diatretol (4), were isolated from the mycelial solid cultures of the basidiomycete Lepista sordida. Their structures were elucidated by spectroscopic means. The isolated diketopiperazines were evaluated for the cytotoxic activity against Astc‐a‐1, Bel 7402, and HeLa cell lines, and their biogenetic pathway was discussed.

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