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Three Genetic Susceptibility Loci Indicate a Role for IL2, REL and CARD9 in Primary Sclerosing Cholangitis

✍ Scribed by Janse, Marcel ;Lamberts, Laetitia E. ;Franke, Lude ;Raychaudhuri, Soumya ;Ellinghaus, Eva ;Boberg, Kirsten Muri ;Melum, Espen ;Schrumpf, Erik ;Bergquist, Annika ;Bjornsson, Einar ;Porte, Robert J. ;Weismüller, Tobias J. ;Wedemeyer, Jochen ;Schramm, Christoph ;Sterneck, Martina ;Günther, Rainer ;Braun, Felix ;Vermeire, Severine ;Henckaerts, Liesbet ;Wijmenga, Cisca ;Ponsioen, Cyriel ;Schreiber, Stefan ;Karlsen, Tom H. ;Franke, Andre ;Weersma, Rinse K.

Book ID
122766028
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
50 KB
Volume
140
Category
Article
ISSN
0016-5085

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✍ Marcel Janse; Laetitia E. Lamberts; Lude Franke; Soumya Raychaudhuri; Eva Elling 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 514 KB

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts. Both environmental and genetic factors contribute to its pathogenesis. To further clarify its genetic background, we investigated susceptibility loci recently ide