Three-frequency RF coil designed for optimized imaging of hyperpolarized, 13C-labeled compounds
✍ Scribed by Ileana Hancu; S. James Wood; Joseph Piel; David B. Whitt; Kenneth M. Fish; Brian K. Rutt; James Tropp; W. Thomas Dixon
- Book ID
- 102534861
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 377 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
Imaging exams involving hyperpolarized, ^13^C‐labeled compounds require novel RF coils for efficient signal utilization. While ^13^C coils are required for mapping the spatial distribution of the hyperpolarized compounds, imaging/pulsing at different frequencies is also needed for scan setup steps prior to the image acquisition. Imaging/pulsing at the ^1^H frequency is typically used for anatomical localization and shimming. Flip angle (FA) calibration, which is difficult or impossible to achieve at the ^13^C frequency, can be accurately performed at the ^23^Na frequency using the natural abundance signal that exists in any living tissue. We demonstrate here a single RF resonant structure that is capable of operating linearly at the ^1^H and ^23^Na frequencies for scan setup steps, and in quadrature at the ^13^C frequency for imaging. Images at the three resonant frequencies of this coil are presented from an exam involving hyperpolarized ^13^C compounds in vivo. Magn Reson Med 60:928–933, 2008. © 2008 Wiley‐Liss, Inc.